Concomitant dimorphism and helical self-assembly in a C_2h-symmetric 'locked' cyclitol

Abstract

A conformationally locked C_2h symmetric tetrol concomitantly crystallized in two polymorphic modifications, differing principally in the mode of molecular association by C-H···O hydrogen bonds; the non-centrosymmetric tetragonal polymorph exhibits two complementary helical molecular arrangements mediated by O-H···O and C-H···O hydrogen bonds.