Synthetic studies directed towards the potent cytotoxic natural product ottelione A: stereoselective construction of the complete framework

Mehta, Goverdhan ; Srinivasa Reddy, D. (1999) Synthetic studies directed towards the potent cytotoxic natural product ottelione A: stereoselective construction of the complete framework Chemical Communications (21). pp. 2193-2194. ISSN 1359-7345

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/1999...

Related URL: http://dx.doi.org/10.1039/A907273J

Abstract

A stereoselective strategy for the rapid acquisition of the complete framework (dideoxyottelione A) of the promising cytotoxic agent ottelione A, with four contiguous stereogenic centres on a hydrindane skeleton and a sensitive 4-methylenecyclohex-2-enone functionality, from the readily available Diels-Alder adduct of 1,2,3,4-tetrachloro-5,5-dimethoxycyclopentadiene and norbornadiene, is delineated.

Item Type:Article
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ID Code:29077
Deposited On:18 Dec 2010 05:38
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