Enantioselective total synthesis of a novel polyketide natural product (+)-integrasone, an HIV-1 integrase inhibitor

Mehta, Goverdhan ; Roy, Subhrangsu (2005) Enantioselective total synthesis of a novel polyketide natural product (+)-integrasone, an HIV-1 integrase inhibitor Chemical Communications (25). pp. 3210-3212. ISSN 1359-7345

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2005...

Related URL: http://dx.doi.org/10.1039/B502024G

Abstract

Enantioselective total synthesis of the recently isolated, novel polyketide natural product (+)-integrasone has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. An enzymatically desymmetrized epoxyquinone building block has been elaborated through a series of regio- , chemo- and stereocontrolled steps to the final bicyclic framework of the natural product.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:29039
Deposited On:18 Dec 2010 05:40
Last Modified:17 May 2016 12:01

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