Enantioselective total synthesis of (+)-Panepophenanthrin, a novel inhibitor of the Ubiquitin-activating enzyme

Mehta, Goverdhan ; Ramesh, Senaiar S (2004) Enantioselective total synthesis of (+)-Panepophenanthrin, a novel inhibitor of the Ubiquitin-activating enzyme Tetrahedron Letters, 45 (9). pp. 1985-1987. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2003.12.149

Abstract

An enantioselective total synthesis of the novel natural product (+)-panepophenanthrin has been accomplished in which a biomimetic Diels-Alder dimerisation is a key step. The monomeric precursor 2 was assembled from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone through a short, simple sequence employing chemo- and stereoselective operations.

Item Type:Article
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ID Code:28994
Deposited On:18 Dec 2010 05:43
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