A total synthesis of (±)-frondosins A and B

Mehta, Goverdhan ; Likhite, Nachiket S. (2008) A total synthesis of (±)-frondosins A and B Tetrahedron Letters, 49 (50). pp. 7113-7116. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2008.09.163

Abstract

A total synthesis of the bioactive meroterpenoid natural products frondosin B and frondosin A (formal) from readily available cyclohexanone and gentisic aldehyde dimethyl ether, involving RCM as the key step to generate the bicyclic 6,7-fused core structure, is outlined.

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