Studies on collagen. I. Structure of the collagen group of proteins

Ramachandran, G. N. ; Kartha, G. (1955) Studies on collagen. I. Structure of the collagen group of proteins Proceedings of the Indian Academy of Sciences, Section A, 42 (5). pp. 215-234. ISSN 0370-0089

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The paper reports the details of the revised structure of collagen. It is composed of three helical polypeptide chains, each of which has ten residues in three turns of a left-handed helix. The three chains are further wound into a superhelix in the form of interwined coiled coils. The major helix is right-handed and makes one turn in thirty residues. The structure has reasonable hydrogen bonds, two for every three residues. The shree-chain cylindrical rods are stacked together in hexagonal array and stabilised by cross-linkages through hydroxyproline side-groups. In trying to fit these in the lattice, a slight uncoiling of the major helix is required, resulting in a repeat of 618 A along the fibre axis. The proposed structure is in good agreement with the infra-red and X-ray data and also fits in broadly with the amino-acid composition and other properties of collagen.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
ID Code:28653
Deposited On:15 Dec 2010 11:46
Last Modified:17 May 2016 11:43

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