Investigational anabolic therapies for osteoporosis

Trivedi, Ritu ; Goswami, Ravinder ; Chattopadhyay, Naibedya (2010) Investigational anabolic therapies for osteoporosis Expert Opinion on Investigational Drugs, 19 (8). pp. 995-1005. ISSN 1354-3784

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Importance of the field: Anabolic therapy, or stimulating the function of bone-forming osteoblasts, is the preferred pharmacological intervention for osteoporosis. Areas covered in this review: We reviewed bone anabolic agents currently under active investigation. The bone anabolic potential of IGF-I and parathyroid hormone-related protein is discussed in the light of animal data and human studies. We also discuss the use of antagonists of the calcium-sensing receptor (calcilytics) as orally administered small molecules capable of transiently elevating serum parathyroid hormone (PTH). Further, we reviewed novel anabolic agents targeting members of the wingless tail (Wnt) signaling family that regulate bone formation including DKK-1, sclerostin, Thp1, and glycogen synthase kinase 3β . We have also followed up on the promise shown by β -blockers in modulating the activity of sympathetic nervous system, thus affecting bone anabolism. We give critical consideration to neutralizing the activity of activin A, a negative regulator of bone mass by soluble activin receptor IIA, as a strategy to promote bone formation. What the reader will gain: Update on various strategies to promote osteoblast function currently under evaluation. Take home message: In spite of favorable results in experimental models, none of these strategies has yet achieved the ultimate goal of providing an alternative to injectable PTH, the sole anabolic therapy in clinical use.

Item Type:Article
Source:Copyright of this article belongs to Informa Healthcare.
Keywords:Bone Remodeling; Neutralizing Antibody; Osteogenic; Osteosarcoma
ID Code:28256
Deposited On:15 Dec 2010 12:21
Last Modified:15 Feb 2011 05:56

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