Reversible peripheral neuropathy in idiopathic hypoparathyroidism

Goswami, R. ; Bhatia, M. ; Goyal, R. ; Kochupillai, N. (2002) Reversible peripheral neuropathy in idiopathic hypoparathyroidism Acta Neurologica Scandinavica, 105 (2). pp. 128-131. ISSN 0001-6314

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We describe a 40-year-old male with idiopathic hypoparathyroidism presenting with tetany, proximal weakness, signs of hypocalcaemia including Chvostek and Trousseau's and diminished tendon reflexes in the upper and lower limbs. Electrophysiological studies revealed a sensory-motor neuropathy, predominantly axonal as evidenced by decreased CMAP amplitudes, with normal distal latencies-velocites, except for median nerve where a prolonged distal latency was observed. Serial nerve conduction studies were performed at repeated intervals for 2 years, while he received treatment for hypoparathyroidism (calcium and vitamin D supplementation). A progressive improvement in neuropathy both clinical and on electrophysiological studies was observed. Occurrence of peripheral neuropathy in hypocalcaemic states such as hypoparathyroidism and its reversibility after normalization of calcium homeostasis lend proof to the role of critical Ca2+ ion concentration in the normal functioning of the peripheral axons.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Hypoparathyroidism; Peripheral Neuropathy; Ca2+
ID Code:28241
Deposited On:15 Dec 2010 12:22
Last Modified:02 Jun 2011 11:39

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