Phenolic glycolipid-I of Mycobacterium leprae induces general suppression of in vitro concanavalin A responses unrelated to leprosy type

Prasad, H. K. ; Mishra, R. S. ; Nath, I. (1987) Phenolic glycolipid-I of Mycobacterium leprae induces general suppression of in vitro concanavalin A responses unrelated to leprosy type The Journal of Experimental Medicine, 165 (1). pp. 239-244. ISSN 0022-1007

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Official URL: http://jem.rupress.org/content/165/1/239.abstract?...

Related URL: http://dx.doi.org/10.1084/jem.165.1.239

Abstract

Using a costimulant assay, in vitro Con A responses of patients across the leprosy spectrum were found to be markedly suppressed by phenolic glycolipid-I (PGL-I), a unique antigen of M. leprae. The degree of inducible suppression as well as the number of leprosy patients showing suppression of mitogenic responses was higher with PGL-I as compared with integral M. leprae (p less than 0.05 to less than 0.01). Both untreated lepromatous (60%) as well as tuberculoid leprosy (67%) patients showed significant suppression ranging from 13 to 64% and 12 to 79%, respectively. Thus, PGL-I appears to have a universal suppressive effect on Con A responses and is unlikely to play a central role in determining the leprosy spectrum.

Item Type:Article
Source:Copyright of this article belongs to Rockefeller University Press.
ID Code:27636
Deposited On:10 Dec 2010 11:55
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