Pathophysiology of catalytic antibodies

Lacroix-Desmazes, Sebastien ; Wootla, Bharath ; Delignat, Sandrine ; Dasgupta, Suryasarathi ; Nagaraja, Valakunja ; Kazatchkine, Michel D. ; Kaveri, Srini V. (2006) Pathophysiology of catalytic antibodies Immunology Letters, 103 (1). pp. 3-7. ISSN 0165-2478

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01652...

Related URL: http://dx.doi.org/10.1016/j.imlet.2005.10.007

Abstract

Immunoglobulins have initially been illustrated as proteins produced by the immune system for binding and neutralizing foreign molecules potentially harmful to the organism. The number of VH, DH, JH, VL and JL genes that encode the variable regions of immunoglobulins and the junctional diversity that occurs at the time of somatic rearrangement determine the extent of the repertoire of antibodies that may be potentially produced by an organism. This potential repertoire includes antibodies the antigen binding site of which may recognize external as well as autologous antigens, or may structurally resemble the active site of enzymes and be endowed with enzymatic activity. Under physiological conditions, B cell clones that produce antibodies naturally endowed with catalytic activity are negatively regulated and subjected to apoptosis. Catalytic antibodies are expressed only following active immunization, or if the physiological regulatory mechanisms that control the expression of catalytic antibody-producing B cell clones are perturbed, e.g. in the context of pregnancy or in the course of autoimmune diseases.

Item Type:Article
Source:Copyright of this article belongs to European Federation of Immunological Societies.
Keywords:Catalytic Antibodies; Autoimmune Diseases; Hemophilia A; Idiotypic Network; Factor VIII
ID Code:26987
Deposited On:08 Dec 2010 12:53
Last Modified:25 Jan 2011 15:58

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