Estrogen modulation of retinol-binding protein in immature chicks: comparison with riboflavin carrier protein

Durga Kumari, B. ; Adiga, P. Radhakantha (1986) Estrogen modulation of retinol-binding protein in immature chicks: comparison with riboflavin carrier protein Molecular and Cellular Endocrinology, 46 (2). pp. 121-130. ISSN 0303-7207

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The kinetics of estrogen (E) modulation of retinol-binding protein (RBP) production in the liver of immature chicks were compared with those governing de novo induction of riboflavin carrier protein (RCP) in the same tissue. A single dose of E markedly enhanced the plasma levels of RBP without any detectable lag period to reach peak value by 24 h and this was followed by a decline to attain the baseline by 4 days. There was no amplification of the response during secondary stimulation unlike the case with RCP induction. With multiple E administration, the 4-fold increased plasma RBP concentrations were sustained at a steady state during both primary and secondary stimulations, whereas concomitant RCP concentration progressively increased with each hormone administration and this response was further amplified during secondary stimulation. Unlike RCP induction, enhanced RBP accumulation was not strictly E dose dependent although a minimal threshold level of the steroid was required to elicit measurable response. Progesterone (P) could neither modulate nor substitute for E in enhancing plasma levels of either of the 2 proteins while the anti-estrogens, en- and zuclomifene citrate severely suppressed the production of both the proteins. RCP induction was completely inhibited by both α -amanitin and cycloheximide for prolonged periods while E-stimulated RBP production was affected only partially by α -amanitin. Likewise, cycloheximide inhibition of RBP accumulation followed a pattern similar to that of hepatic general protein synthesis.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Estrogen; Retinol-binding Protein; Riboflavin Carrier Protein; Progesterone; Clomifene Citrate; α-amanitin; Cycloheximide
ID Code:26830
Deposited On:08 Dec 2010 13:07
Last Modified:13 May 2011 04:47

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