Ramana Murti, J. ; Adiga, P. R. ; Padmanaban, G. (1991) Estradiol - 17β induces polyaromatic hydrocarbon-inducible cytochrome P-450 in chicken liver Biochemical and Biophysical Research Communications, 175 (3). pp. 928-935. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(91)91654-U
Abstract
A cDNA clone has been isolated from a chicken liver library prepared against messenger RNA isolated after chronic estradiol-17β treatment. The clone, pP-450 IA - 61, has an insert of 900nt and the sequence shows high homology to CYPIA2 subfamily from four other species. A single injection of estradiol-17β to immature chicken results in a striking induction of mRNA hybridizing to labeled pP-450IA - 61. The probe also hybridizes to mRNA induced by 3 - methylcholanthrene in chicken. These results offer direct proof for the similarity in the mode of action at the transcriptional level of polyaromatic hydrocarbons and estrogenic compounds.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 26751 |
| Deposited On: | 08 Dec 2010 13:15 |
| Last Modified: | 14 Jun 2011 08:48 |
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