Folate receptor endocytosis and trafficking

Sabharanjak, Shefali ; Mayor, Satyajit (2004) Folate receptor endocytosis and trafficking Advanced Drug Delivery Reviews, 56 (8). pp. 1099-1109. ISSN 0169-409X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01694...

Related URL: http://dx.doi.org/10.1016/j.addr.2004.01.010

Abstract

Folate absorption is primarily mediated by a membrane transporter with micro-molar affinities for folates. Paradoxically, folates are only present at low nanomolar concentrations in extracellular milieus; membrane folate receptors (FRs) with nanomolar affinities for folates are likely to substantially modulate folate availability for these transporters. Functional isoforms of FRs are anchored to the membrane by a glycolipid anchor, the glycosylphosphatidylinositol (GPI) anchor. In this chapter we discuss recent insights that have been obtained with regards to GPI-anchored protein trafficking in the context of folate transport via the GPI-anchored FR. Specifically, we focus on recent advances in elucidating the pathways and mechanisms of endocytic sorting of the GPI-anchored FR, and the connection with membrane rafts.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Folate Receptor Recycling; Folate Receptors in Lipid Rafts; Sorting of Receptors in Endosomes; GEECs; Glycosylphosphatidylinositol Anchored Proteins
ID Code:26696
Deposited On:08 Dec 2010 13:22
Last Modified:01 Mar 2011 11:25

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