Stress response in pathogenic bacteria

Chowdhury, Rukhsana ; Sahu, Gautam K. ; Das, Jyotirmoy (1996) Stress response in pathogenic bacteria Journal of Biosciences, 21 (2). pp. 149-160. ISSN 0250-5991

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Bacterial pathogens survive under two entirely different conditions, namely, their natural environment and in their hosts. Response of these pathogens to stresses encountered during transition from the natural environment to human hosts has been described. The virulence determinants of pathogenic bacteria are under the control of transcriptional activators which respond to fluctuations in growth temperature, osmolarity, metal ion concentration and oxygen tension of the environment. The regulation of stress induced genes may occur at the level of transcription or translation or by post-translational modifications. Under certain stress conditions local changes in the superhelicity of DNA induce or repress genes. In addition to their role in survival of bacteria under stressful situations, the stress induced proteins are also implicated in the manifestation of pathogenicity of bacterial pathogensin vivo.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Temperature Stress; Virulence Genes; Heat Shock Proteins; Anaerobiosis; Osmotic Stress; Metal Ions
ID Code:26581
Deposited On:08 Dec 2010 13:32
Last Modified:17 May 2016 09:52

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