Penicillin binding proteins of Vibril cholerae

Sengupta, Tapas K. ; Chatterjee, Anadi N. ; Das, Jyotirmoy (1990) Penicillin binding proteins of Vibril cholerae Biochemical and Biophysical Research Communications, 171 (3). pp. 1175-1181. ISSN 0006-291X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...

Related URL: http://dx.doi.org/10.1016/0006-291X(90)90808-Z

Abstract

Eleven penicillin binding proteins (PBPs) of Vibril cholerae have been identified using [125I] labelled p-hydroxybenzyl penicillin (PenX). These proteins are localised in the inner membrane and have molecular weights ranging from 97,000 to 22,000. Neutral hydroxylamine released the labelled PenX from the PBPs and pretreatment with cold benzyl penicillin inhibited labelling completely. The PBP 4 is the most sensitive target for cephaloridine and aztreonam. Cephaloridine also binds to three other high molecular weight PBPs, 1, 2 and 3. Aztreonam in addition to PBP 4, has affinity for another low molecular weight PBP, PBP 7. Mecillinam has affinity for PBPs 1, 4 and 11.

Item Type:Article
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ID Code:26539
Deposited On:08 Dec 2010 13:35
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