Stabilization of microtubules by lithium ion

Bhattacharyya, B. ; Wolff, J. (1976) Stabilization of microtubules by lithium ion Biochemical and Biophysical Research Communications, 73 (2). pp. 383-390. ISSN 0006-291X

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Lithium ion, in concentrations of 0.2 - 1.0 mM, promotes tubulin polymerization, provided small concentrations of Mg++ ion are present. This effect of lithium on polymerization, at suboptimal concentration of magnesium, is additive for the two metal ions. Both Li+ and Mg++ protect microtubules against the depolymerizing effects of colchicine or vinblastine.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:26312
Deposited On:06 Dec 2010 12:44
Last Modified:18 May 2011 07:05

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