Charge effect on the colchicine binding-site of tubulin

Roychowdhuri, Sukla ; Banerjee, Asok ; Bhattacharyya, B. (1983) Charge effect on the colchicine binding-site of tubulin Biochemical and Biophysical Research Communications, 113 (2). pp. 384-390. ISSN 0006-291X

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Poly (L-lysine) was found to enhance colchicine binding activity of brain tubulin to a several folds. Bases of biological interests that were tested and found to be inactive were spermine, spermidine and even L-lysine. Part of this enhance binding is due to the increase in the affinity of colchicine-tubulin interaction in the presence of poly (L-lysine). Moreover, poly (L-lysine) stabilized the colchicine binding site of tubulin against thermal denaturation.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:26177
Deposited On:06 Dec 2010 12:58
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