Colchicine binding activity of rat brain polysomes

Chakrabarty, S. ; Sen, K. ; Bhattacharyya, B. ; Biswas, B. B. (1983) Colchicine binding activity of rat brain polysomes Journal of Biosciences, 5 (3). pp. 203-208. ISSN 0250-5991

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In this communication, we report the presence of a unique colchicine-binding activity in the polysomes of rat brain. This drug-binding property, is somewhat similar to that of tubulin isolated from many sources; however, it differs in several bio-chemical characteristics such as (i) thermal stability of colchicine-binding site, (ii) protection of binding site by vinblastine and (iii) time required for binding equilibration. Such binding of colchicine to the polysomes is most probably due to the presence of a nascent peptide chain of tubulin in the polysome.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Colchicine-binding Activity; Tubulin Polysomes; Nascent Peptide Chain
ID Code:26138
Deposited On:06 Dec 2010 13:02
Last Modified:17 May 2016 09:28

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