Panda, S. K. ; Bhan, M. K. ; Guha, D. K. ; Gupta, A. ; Datta, R. ; Zuckerman, A. J. ; Nayak, N. C. (1988) Significance of maternal and infant serum antibodies to hepatitis B core antigen in hepatitis B virus infection of infancy Journal of Medical Virology, 24 (3). pp. 343-349. ISSN 0146-6615
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jmv.189...
Related URL: http://dx.doi.org/10.1002/jmv.1890240311
Abstract
The significance of IgM and IgG class antibodies to hepatitis B virus (HBV) core component (anti-HBc) was investigated in a study of maternal-fetal HBV transmission. An IgM anti-HBc response was lacking in the majority (49/53) of HBV-infected infants. This antibody thus cannot be used as an indicator of transplacental infection. However, most infants who became HBsAg positive during the first 6 months of life acquire infection in the perinatal period rather than transplacentally. Passively transferred maternal IgG anti-HBc in the infant and additional IgM anti-HBc positively in the carrier mother have no modulating influence on HBV infection of infants born to HBV carrier women.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| Keywords: | HBV Infection in Infants; Transplacental Transmission; IgM and IgG Anti-HBc |
| ID Code: | 24664 |
| Deposited On: | 29 Nov 2010 10:22 |
| Last Modified: | 13 Jul 2012 11:41 |
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