Rizvi, Tahir Aziz ; Mathur, Meera ; Nayak, Nabeen Chandra (1989) Enhancement of aflatoxin B1-induced hepatocarcinogenesis in rats by partial hepatectomy Virchows Archiv - B: Cell Pathology, 56 (1). pp. 345-350. ISSN 0340-6075
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Official URL: http://www.springerlink.com/content/6411020165642n...
Related URL: http://dx.doi.org/10.1007/BF02890036
Abstract
The effect of enhanced cell replication induced by partial hepatectomy (PH) in aflatoxin B1 (AFB1)-induced hepatocarcinogenesis has been studied in rats of the inbred As2 strain. Animals were given 0.25 mg/kg body weight of AFB1 as a single intraperitoneal dose 24 h after PH. Nonhepatectomized animals given the same dose of AFB1 served as controls. Neoplastic nodules and hepatocellular carcinoma (HCC) were detected respectively in 100% and 90% of hepatectomized animals sacrificed between 55 and 65 weeks after AFB1 administration. None of the ten non-hepatectomized rats sacrificed at this time interval showed HCC or neoplastic nodules. On histochemical staining the tumour population was found to be heterogeneous. Thus PH resulted in enhancement of AFB1-induced hepatocarcinogenesis in rats of the AS2 strain.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer-Verlag. |
| Keywords: | Aflatoxin B; Hepatocarcinogenesis; Cell Replication |
| ID Code: | 24652 |
| Deposited On: | 29 Nov 2010 10:09 |
| Last Modified: | 04 Mar 2011 03:36 |
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