Development of candidate rotavirus vaccines derived from neonatal strains in India

Glass, Roger I. ; Bhan, Maharaj K. ; Ray, Pratima ; Bahl, Rajiv ; Parashar, Umesh D. ; Greenberg, Harry ; Rao, C. Durga ; Bhandari, Nita ; Maldonado, Yvonne ; Ward, Richard L. ; Bernstein, David I. ; Gentsch, Jon R. (2005) Development of candidate rotavirus vaccines derived from neonatal strains in India The Journal of Infectious Diseases, 192 (S1). S30-S35. ISSN 0022-1899

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The need for a rotavirus vaccine in India is based on the enormous burden associated with the <100,000 deaths due to rotavirus diarrhea that occur annually among Indian children. Two rotavirus strains identified during nosocomial outbreaks of rotavirus infection in New Delhi and Bangalore, India, more than a decade ago are being developed as live oral vaccines. Infected newborns had no symptoms, shed virus for up to 2 weeks after infection, mounted a robust immune response, and demonstrated protection against severe rotavirus diarrhea after reinfection. The 2 strains are naturally occurring bovine-human reassortants. The New Delhi strain, 116E, is characterized as having a P[11],G9 genotype, and the Bangalore strain, I321, is characterized as having a P[11],G10 genotype. The strains have been prepared as pilot lots for clinical trials to be conducted in New Delhi. This unique project, which is developing a new rotavirus vaccine in India with the use of Indian strains, an Indian manufacturer, and an Indian clinical development program, aims to expedite introduction of rotavirus vaccines in India.

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Source:Copyright of this article belongs to Infectious Diseases Society of America.
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Deposited On:08 Oct 2010 09:15
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