31P saturation transfer and phosphocreatine imaging in the monkey brain

Mora, B. ; Narasimhan, P. T. ; Ross, B. D. ; Allman, J. ; Barker, P. B. (1991) 31P saturation transfer and phosphocreatine imaging in the monkey brain Proceedings of the National Academy of Sciences of the United States of America, 88 (19). pp. 8372-8376. ISSN 0027-8424

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Official URL: http://www.pnas.org/content/88/19/8372.short


31P magnetic resonance imaging with chemical-shift discrimination by selective excitation has been employed to determine the phosphocreatine (PCr) distribution in the brains of three juvenile macaque monkeys. PCr images were also obtained while saturating the resonance of the gamma-phosphate of ATP, which allowed the investigation of the chemical exchange between PCr and the gamma-phosphate of ATP catalyzed by creatine kinase. Superposition of the PCr images over the proton image of the same monkey brain revealed topological variations in the distribution of PCr and creatine kinase activity. PCr images were also obtained with and without visual stimulation. In two out of four experiments, an apparently localized decrease in PCr concentration was noted in visual cortex upon visual stimulation. This result is interpreted in terms of a possible role for the local ADP concentration in stimulating the accompanying metabolic response.

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