A convenient method for the synthesis of peptides acylated with palmitic acid specifically at cysteine thiol

Nagaraj, Ramakrishnan ; Joseph, Mercy (1993) A convenient method for the synthesis of peptides acylated with palmitic acid specifically at cysteine thiol Bioorganic & Medicinal Chemistry Letters, 3 (6). pp. 1025-1028. ISSN 0960-894X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09608...

Related URL: http://dx.doi.org/10.1016/S0960-894X(00)80280-2

Abstract

Acylation of a cysteine containing peptide with palmitoyl chlroide, when attached to a solid support, followed by acidolytic cleavage of the peptide from the resin, to generate the fatty acylated peptide was explored. Our results indicate that this is a convenient method to synthesize peptides specifically acylated at the thiol group of cysteine. Acylation of a cysteine containing peptide with palmitoyl chloride, when attached to a solid support, followed by acidolytic cleavage of the peptide from the resin, to generate the fatty acylated peptide is a convenient method to synthesize peptides specifically acylated at the thiol group of cysteine.

Item Type:Article
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Deposited On:01 Dec 2010 12:46
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