Sagar, Amara J. ; Mahalakshmi, Yeditha V. ; Nagaraj, Ramakrishnan ; Pandit, Madhusudan W. (1989) Antigenic sites on ribonuclease A synthetic peptides corresponding to the sites 37-42 and 83-88 on ribonuclease A show immunogenicity International Journal of Peptide and Protein Research, 33 (6). pp. 452-456. ISSN 0367-8377
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-...
Related URL: http://dx.doi.org/10.1111/j.1399-3011.1989.tb00222.x
Abstract
Two hexapeptides NH2-Lys-Asp-Arg-Cys-Lys-Pro-COOH and NH2-Asp-Cys-Arg-Glu-Thr-Gly-COOH corresponding to the strong hydrophilic regions 37-42 and 83-88, respectively, on ribonuclease A were synthesized by solid-phase method. These synthetic peptides showed antigenic characteristics and provided an experimental validity to the prediction made earlier, supporting the view that highly hydrophilic regions on the protein have a good correlation with their being potentially antigenic.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Munksgaard International Publishers. |
| Keywords: | Antigenic Sites; Ribonuclease A; Immunogenicity; Peptide Synthesis; Hydrophilicity |
| ID Code: | 23938 |
| Deposited On: | 01 Dec 2010 12:53 |
| Last Modified: | 25 Jan 2011 11:10 |
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