Interaction of a hydrophobic model peptide and its fatty acid derivative with lipid vesicles

Joseph, M. ; Nagaraj, R. (1988) Interaction of a hydrophobic model peptide and its fatty acid derivative with lipid vesicles FEBS Letters, 238 (2). pp. 411-414. ISSN 0014-5793

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001457...

Related URL: http://dx.doi.org/10.1016/0014-5793(88)80522-2

Abstract

The interaction of a peptide [Lys-Phe-Phe-Phe-Ile-Ile-Trp-OCH3] and its fatty acid derivatives [Lys-(e-palmitoyl)-Phe-Phe-Phe-Ile-Ile-Trp-OCH3 and Lys-{ε-12-(9-anthroyloxy)stearic acid}-Phe-Phe-Phe-Ile-Ile-OCH3] with model membranes was investigated by fluorescence spectroscopy. The emission characteristics of the Trp fluorophore indicated that only the peptide with the fatty acid chain is associated with lipid vesicles. Quenching experiments with spin probes suggest an orientation for the fatty acylated peptide wherein the fatty acid chain is perpendicular to the bilayer surface and the peptide chain parallel to the bilayer surface.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords:Hydrophobic Peptide; Fatty Acid Acylation; Fluorescence Spectroscopy; Fluorescence Quenching
ID Code:23848
Deposited On:01 Dec 2010 13:02
Last Modified:17 May 2016 07:39

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