Iodide transport in isolated cells of mouse submaxillary gland

Banerjee, R. K. ; Bose, A. K. ; Chakraborty, T. K. ; De, P. K. ; Datta, A. G. (1986) Iodide transport in isolated cells of mouse submaxillary gland Journal of Biosciences, 10 (3). pp. 303-309. ISSN 0250-5991

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A method has been developed to isolate cells from the submaxillary gland of mouse by treatment with pronase. Three fractions of cells have been isolated having almost equal iodide concentrating activity. The isolated cells show time dependent uphill transport of iodide. The transport is substrate-saturable, having aK m value of 0.3 μM for iodide. The transport is sensitive to antithyroid drugs, metabolic inhibitors and to some extent to ouabain. Pseudohalide such as thiocyanate competes with the transport of iodide. Thyroid hormones or thyroid stimulating hormone have no significant effect on the iodide transport in these cells.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Iodide Transport; Iodide Concentration; Isolated Cells of Submaxillary Gland
ID Code:23610
Deposited On:26 Nov 2010 08:41
Last Modified:17 May 2016 07:24

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