Effect of glucagon on alanine 2-oxoglutarate aminotransferase

Banerjee, Ratna B. ; Bhadra, Ranjan ; Datta, Asoke G. (1983) Effect of glucagon on alanine 2-oxoglutarate aminotransferase Biochemical and Biophysical Research Communications, 115 (2). pp. 506-511. ISSN 0006-291X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...

Related URL: http://dx.doi.org/10.1016/S0006-291X(83)80173-9


Alanine-2-oxoglutarate aminotransferase activity in mouse liver is stimulated by the intravenous injection of glucagon. The stimulation is abolished by pretreatment with actinomycin D indicating that the increased activity is probably due to new enzyme formation. Administration of dibutyryl cyclic AMP, isoproterenol, an activator of adenyl cyclase and theophylline, an inhibitor of phosphodiesterase also increases the enzyme activity suggesting the involvement of cyclic AMP in glucagon-mediated increase of enzyme activity.

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