Is brain a gluconeogenic organ?

Bhattacharya, Sikha Bettina ; Datta, Asoke G. (1993) Is brain a gluconeogenic organ? Molecular and Cellular Biochemistry, 125 (1). pp. 51-57. ISSN 0300-8177

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Glucagon increased the activities of alanine amino transferase (AAT), fructose-1:6-bisphosphatase (fru-P2ase) and glucose-6-phosphatase (G-6-Pase) in goat brain tissue by about 100%, 150% and 50% respectively. These increase in activities were reversed by β-antagonists propranolol. Well known α-agonist and antagonist like phenylephrine and phenoxybenzamine also increased AAT and G-6-Pase activities and these increased activities were reversed by propranolol. Phenylephrine and phenoxybenzamine however did not increase brain Fru-P2ase activity.However the most interesting finding is that cerebral cortical slices could produce glucose from alanine and this glucose production was enhanced by glucagon, phenylephrine and phenoxybenzamine. Propranolol reversed the effects of these agonists and antagonist to a great extent. From all these experiments we suggest brain to be a gluconeogenic organ although much less efficient than liver.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
Keywords:Brain Slices; Alanine Aminotransferase Fructose-1:6-Bisphosphatase; Glucose-6-phosphatase; α-agonist and Antagonist; Gluconeogenesis from Alanine
ID Code:23580
Deposited On:26 Nov 2010 08:37
Last Modified:30 May 2011 11:36

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