Hasan, A. ; Satyanarayana, M. ; Mishra, A. ; Bhakuni, D. S. ; Pratap, Ram ; Dube, A. ; Guru, P. Y. (2006) Acyclic pyrazolo[3,4-d]pyrimidine nucleoside as potential leishmaniostatic agent Nucleosides, Nucleotides and Nucleic Acids, 25 (1). 55 - 60. ISSN 1525-7770
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Related URL: http://dx.doi.org/10.1081/15257770500379017
Abstract
A new synthesis of 6-amino-1-hydroxyethoxymethyl-4 (5H)-oxopyrazolo[3, 4]pyrimidine (4) has been mentioned. Compound 4 exhibited inhibition of amastigotes of Leishmania donovani to the extent of 89% at 30 μg/mL, whereas iso-guanine analogue 5 had the inhibition only to the extent of 52.8% at 100 μg/mL in vitro. In hamster model the maximum inhibitory response for compound 4 against amastigotes multiplication was observed to be 94% at 50 Mug/kg single dose for 5 consecutive days.
| Item Type: | Article |
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| Source: | Copyright of this article belongs to Taylor & Francis Group. |
| Keywords: | Leishmania donovani; Amastigotes; Promastigotes; Hamster; Leishmaniostatic; Pyrazolo[3,4-D]Pyrimidine |
| ID Code: | 2351 |
| Deposited On: | 07 Oct 2010 09:11 |
| Last Modified: | 16 May 2016 13:20 |
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