Acyclic pyrazolo[3,4-d]pyrimidine nucleoside as potential leishmaniostatic agent

Hasan, A. ; Satyanarayana, M. ; Mishra, A. ; Bhakuni, D. S. ; Pratap, Ram ; Dube, A. ; Guru, P. Y. (2006) Acyclic pyrazolo[3,4-d]pyrimidine nucleoside as potential leishmaniostatic agent Nucleosides, Nucleotides and Nucleic Acids, 25 (1). 55 - 60. ISSN 1525-7770

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Related URL: http://dx.doi.org/10.1081/15257770500379017

Abstract

A new synthesis of 6-amino-1-hydroxyethoxymethyl-4 (5H)-oxopyrazolo[3, 4]pyrimidine (4) has been mentioned. Compound 4 exhibited inhibition of amastigotes of Leishmania donovani to the extent of 89% at 30 μg/mL, whereas iso-guanine analogue 5 had the inhibition only to the extent of 52.8% at 100 μg/mL in vitro. In hamster model the maximum inhibitory response for compound 4 against amastigotes multiplication was observed to be 94% at 50 Mug/kg single dose for 5 consecutive days.

Item Type:Article
Source:Copyright of this article belongs to Taylor & Francis Group.
Keywords:Leishmania donovani; Amastigotes; Promastigotes; Hamster; Leishmaniostatic; Pyrazolo[3,4-D]Pyrimidine
ID Code:2351
Deposited On:07 Oct 2010 14:41
Last Modified:16 May 2011 12:44

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