Immunologic unresponsiveness in leprosy is mediated by modulation of E-receptor

Muthukkaruppan, Veerappan ; Chakkalath, Hrishikesh R. ; James, Mathew M. (1987) Immunologic unresponsiveness in leprosy is mediated by modulation of E-receptor Immunology Letters, 15 (3). pp. 199-204. ISSN 0165-2478

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By using an indirect immunofluorescence technique with OKT3 and OKT11 monoclonal antibodies, the percentage of CD2 positive cells was found to be reduced in the peripheral blood of bacterial index positive lepromatous leprosy patients; however, in these patients, CD3 positive cells were at the normal level. Further, CD2 positive cells attained the normal proportion in lepromatous patients when mycobacterial load was reduced. Both CD2 and CD3 receptors were expressed at the normal level in tuberculoid leprosy patients. Prior treatment of peripheral blood mononuclear cells from healthy controls with Mycobacterium leprae significantly decreased the percentage of CD2 but not CD3 positive cells. Such a modulation of CD2 on T cells also resulted in blocking the lymphoproliferative response induced by mitogen and antigen. These results suggest that there is a strong correlation between CD2 modulation and immunologic unresponsiveness in leprosy.

Item Type:Article
Source:Copyright of this article belongs to European Federation of Immunological Societies.
Keywords:E-receptor; Mycobacterium Leprae; Leprosy; Unresponsiveness; Immunofluorescence; Lymphoproliferation
ID Code:23374
Deposited On:25 Nov 2010 09:09
Last Modified:25 Nov 2010 09:09

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