Biosynthesis of tylophorine and tylophorinine

Bhakuni, Dewan S. ; Mangla, Virendra K. (1981) Biosynthesis of tylophorine and tylophorinine Tetrahedron, 37 (2). pp. 401-407. ISSN 0040-4020

Full text not available from this repository.

Official URL:

Related URL:


Administration of 3,4-dihydroxyphenyl[2-14C] alanine to young Tylophora asthmatica plants revealed that ring B and carbon atoms C9 and C7 of tylophorine and tylophorinine are derived from dopa. Tracer experiments with 6,7-diphenylhexahydroindolizines (1-7) and (26) demonstrated that compound 1 is efficiently and specifically incorporated into tylophorine (13) and tylophorinine (16). Compounds (3), (4) and (26) were not metabolized by the plants to form (13) and (16) whereas (5) and (6) were utilized to yield (13) and (16). Compound (2) was very poorly converted into (13) and (16) and thus is not on the major biosynthetic pathway of (13) and (16).

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:2308
Deposited On:07 Oct 2010 09:56
Last Modified:16 May 2011 07:31

Repository Staff Only: item control page