Role of linkers in communication between protein modules

Gokhale, Rajesh S. ; Khosla, Chaitan (2000) Role of linkers in communication between protein modules Current Opinion in Chemical Biology, 4 (1). pp. 22-27. ISSN 1367-5931

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S13675...

Related URL: http://dx.doi.org/10.1016/S1367-5931(99)00046-0

Abstract

Multidomain proteins are common in a variety of cellular processes. Their domains are interconnected through short stretches of amino acid residues referred to as linkers. Recent studies on many systems have provided compelling evidence that linkers are more than simple covalent connectors. They also perform the important task of establishing communication between the different functional modules that exist within such proteins.

Item Type:Article
Source:Copyright of this article belongs to Current Opinion Journals.
Keywords:Linkers; Src Kinases; Multi-domain Proteins; Modular Polyketide Synthases; DEBS
ID Code:23070
Deposited On:25 Nov 2010 13:36
Last Modified:02 Jun 2011 07:11

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