The biosynthesis of the alkaloids of cissampelos pareira linn

Bhakuni, Dewan S. ; Jain, Sudha ; Chaturvedi, Rekha (1987) The biosynthesis of the alkaloids of cissampelos pareira linn Tetrahedron, 43 (17). pp. 3975-3982. ISSN 0040-4020

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4020(01)81679-3

Abstract

Tracer experiments show that the bisbenzylisoquinoline alkaloid, (S,R)-hayatidin (10) is stereospecifically biosynthesized in young Cissampelos pareira Linn plants by intermolecular oxidative coupling of (S)-(5)-and (R)-(3), N-methylcoclaurines whereas (R,R)-isochondrodendrine (14) and (R,R)-bebeerine (12) are formed in the plants by oxidative dimerization of (R)-N-methylcoclaurine (3).

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