Biosynthesis of tetrahydropalmatine and palmatine

Bhakuni, Dewan S. ; Jain, Sudha ; Gupta, Sandeep (1980) Biosynthesis of tetrahydropalmatine and palmatine Tetrahedron, 36 (17). pp. 2491-2495. ISSN 0040-4020

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The incorporation of (±)-norlaudanosoline, norprotosinomenine, nororientaline, norlaudanidine, reticuline and laudanosine into tetrahydropalmatine and palmatine has been studied, and specific utilization of reticuline demonstrated. Feeding of (±)-[N-methyl-14C] reticuline showed that C atom 8 of tetrahydropalmatine and palmatine are formed by oxidative cyclisation of the N-Me group of reticuline. Parallel experiments with (R)-; and (S)-, reticulines demonstrated specific incorporation of (R)- isomer into these bases. Feeding experiments also revealed that the plants can convert tetrahydropalmatine into palmatine with high efficiency.

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ID Code:2277
Deposited On:07 Oct 2010 11:39
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