The biosynthesis of nornuciferine-I(2-methoxy-6aα-aporphine-1-ol)

Bhakuni, Dewan S. ; Jain, Sudha ; Chaturvedi, Rekha (1979) The biosynthesis of nornuciferine-I(2-methoxy-6aα-aporphine-1-ol) Tetrahedron, 35 (19). pp. 2323-2326. ISSN 0040-4020

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The incorporation of (±)-norcoclaurine, (±)-coclaurine, (±)-N-methylcoclairine, (±)-N-methylnorcoclaurine into nornuciferine-I in Croton sparsiflorus morong has been studied, and the specific utilization of the (±)-N-methylcoclaurine demonstrated. The evidence supports the direct oxidative coupling of (+)-(S)-N-methylcoclaurine to give N-methylcrotsparine, which in turn is shown to be a specific precursor of nornuciferine-I. The experiments also show that N-methylcrotsparine is reduced to N-methylcrotsparinol and it is N-methylcrotsparinol-I which is preferentially dehydrated and rearranged to nornuciferine-I.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:2268
Deposited On:07 Oct 2010 11:40
Last Modified:16 May 2011 07:38

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