Short Communication Residence time distribution in the extra capillary space of hollow fiber bioreactors

Abstract

The residence time distribution (RTD) in the extracapillary space (ECS) of hollow fiber bioreactors (HFBRs) has been studied using a high molecular weight protein, bovine serum albumin, as a tracer. The RTD measurements have been carried out at different conditions of flow in the ECS and the intracapillary space (ICS). The RTD results obtained give an indication of the flow patterns existing in the ECS. The implications of these studies on cell cultivation as well as product recovery from HFBRs have been discussed.