Latif, Nahid Ali ; Bachhawat, Bimal Kumar (1987) The effect of surface-coupled antigen of liposomes in immunopotentiation Immunology Letters, 15 (1). pp. 45-51. ISSN 0165-2478
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/016524...
Related URL: http://dx.doi.org/10.1016/0165-2478(87)90075-7
Abstract
The effect of surface coupled antigens of liposomes on the immunological response has been investigated. Lysozyme was covalently coupled to neutral and positively charged liposomes using glutaraldehyde. Subcutaneous administration of these preparations stimulated a significant antibody response higher than that elicited by the antigen entrapped in neutral liposomes. Immunization by liposomal antigens together with complete Freund's adjuvant resulted in strong immune responses, highest with the antigen coupled to neutral and positively charged liposomes followed by the antigen entrapped in neutral liposomes. Primary and secondary immunization with lysozyme, both entrapped and coupled to liposomes, evoked an IgG response.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to European Federation of Immunological Societies. |
| Keywords: | Liposome; Lysozyme; Surface-coupled; Entrapped; Immune Response |
| ID Code: | 2201 |
| Deposited On: | 08 Oct 2010 07:34 |
| Last Modified: | 07 Jan 2011 09:52 |
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