Synthetic glycolipids: interaction with galactose-binding lectin and hepatic cells

Ghosh, P. ; Bachhawat, B. K. ; Surolia, A. (1981) Synthetic glycolipids: interaction with galactose-binding lectin and hepatic cells Archives of Biochemistry and Biophysics, 206 (2). pp. 454-457. ISSN 0003-9861

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Lactosyl- and melibiosyl-phosphatidylethanolamine prepared by reductive animation with sodium cyanoborohydride were incorporated into small unilamellar liposomes. Lactosyland melibiosyl-phosphatidylethanolamine liposomes are aggregated by Ricinus communis agglutinin whereas Banderiaea simplicifolia isolectin I aggregates only melibiosyl-phosphatidylethanolamine liposomes. The association constant (Ka) values of interactions of R. communis agglutinin and glycolipids were 5 × 105 and 1.2 × 105 M−1 for lactosyl- and melibiosyl-phosphatidylethanolamine, respectively, whereas the Ka for the interaction of B. simplicifolia isolectin I for melibiosyl-phosphatidylethanolamine was found to be 6 × 105 M−1. The rates of aggregation of these liposomes are strikingly influenced by the amount of glycolipid incorporated into them. In vivo studies indicate that lactosyl-phosphatidyl-ethanolamine-containing liposomes are rapidly taken up by hepatic cells due to binding of their β-D-galactopyranosyl residues by the hepatic galactose-binding lectin.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:2191
Deposited On:08 Oct 2010 07:35
Last Modified:14 Jun 2011 06:12

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