Transdermal immunization with large proteins by means of ultradeformable drug carriers

Paul, Amla ; Cevc, Gregor ; Bachhawat, Bimal K. (1995) Transdermal immunization with large proteins by means of ultradeformable drug carriers European Journal of Immunology, 25 (12). pp. 3521-3524. ISSN 0014-2980

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Official URL: http://www3.interscience.wiley.com/journal/1121590...

Related URL: http://dx.doi.org/10.1002/eji.1830251248

Abstract

By means of novel, ultradeformable and self-optimizing agent carriers called transfersomes, large molecules can be brought into the body through intact permeability barriers. This permits non-invasive immunization through normal skin and gives rise to a similar or even slightly higher antibody titer than subcutaneous injections of the same immunogen formulation. The former type of immunization also results in a higher IgA/IgG ratio in the blood than the repeated immunogen injections, as shown here for a soluble protein, human serum albumin, as well as for an integral membrane protein, gap junction protein, in mice.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Transfersome; Liposome; Drug Delivery; Non-invasive Vaccine; Gap Junction Protein
ID Code:2189
Deposited On:08 Oct 2010 07:37
Last Modified:12 May 2011 11:14

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