Monosialoganglioside liposome-entrapped enzyme uptake by hepatic cells

Surolia, Avadhesha ; Bachhawat, B. K. (1977) Monosialoganglioside liposome-entrapped enzyme uptake by hepatic cells Biochimica et Biophysica Acta: General Subjects, 497 (3). pp. 760-765. ISSN 0304-4165

Full text not available from this repository.

Official URL:

Related URL:


Monosialogangliosde liposomes are rapidly taken up by the liver as compared to dicetylphosphate, phosphatidic acid or neutral liposomes. Asialoganglioside GM1 liposomes are taken up with the same avidity as ganglioside GM1 liposomes. Competition experiments with asialofetuin suggest that this uptake is mediated by specific recognition of the terminal galactose residues of the glycolipid liposomes by the receptor present on the plasma membrane of the parenchymal cells of liver. Thus liposomes containing glycolipids with terminal β-galactosyl residues should provide an approach for specifically directing biologically active molecules to liver parenchymal cells.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:2182
Deposited On:08 Oct 2010 07:38
Last Modified:12 May 2011 12:10

Repository Staff Only: item control page