Studies on regulation of chorionic gonadotropin secretion in primates

Jagannadha Rao, A. ; Mathialagan, N. ; Kotagi, S. G. ; Moudgal, N. R. (1984) Studies on regulation of chorionic gonadotropin secretion in primates Journal of Biosciences, 6 (2). pp. 97-106. ISSN 0250-5991

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Official URL: http://www.ias.ac.in/jarch/jbiosci/6/97-106.pdf

Related URL: http://dx.doi.org/10.1007/BF02716721

Abstract

The regulation of secretion of chorionic gonadotropin in primates has been studied using bothin vivo andin vitro models.In vivo studies using the pregnant bonnet monkey revealed that at the doses tested, the administration of progesterone or estradiol 17β in combination or alone did not result in any appreciable change in the duration or magnitude of serum chorionic gonadotropin levels. However, administration of lutropin-releasing hormone by intravenous route resulted in significant increase in chorionic gonadotropin levels within 30-60 min and the extent of stimulation seemed to depend on the state of pregnancy. Forin vitro studies, explants or cells prepared from first trimester human placenta has been used. The functional integrity of these cells has been established by demonstrating the binding of [125I]-labelled human chorionic gonadotropin antibody to the cells as well as the synthesis of [3H]-labelled human chorionic gonadotropin.In vitro studies using the cells revealed that addition of lutropin-releasing hormone caused a significant increase in chorionic gonadotropin and estradiol 17β secreted into the medium. Thus bothin vivo andin vitro results suggest that lutropin-releasing hormone could be one of the factors involved in regulation of chorionic gonadotropin secretion in primates.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Chorionic Gonadotropin; Placenta; Lutropin-releasing Hormone; Regulation; Primates
ID Code:21667
Deposited On:22 Nov 2010 11:05
Last Modified:17 May 2016 05:51

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