Effect of chronic neutralization of endogenous FSH on testicular function in the adult male bonnet monkey - assessment using biochemical parameters

Sheela Rani, C. S. ; Murty, G. S. R. C. ; Moudgal, N. R. (1978) Effect of chronic neutralization of endogenous FSH on testicular function in the adult male bonnet monkey - assessment using biochemical parameters International Journal of Andrology, 1 (1-6). pp. 489-500. ISSN 0105-6263

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-...

Related URL: http://dx.doi.org/10.1111/j.1365-2605.1978.tb00620.x

Abstract

The effect of long-term passive immunization with a specific homologous antiserum to ovine FSH on testicular function in the adult bonnet monkey was studied. Testicular function was assessed by studying biochemical parameters such as hyaluronidase activity and the rate of incorporation of [3H]thymidine into DNA of testis in vitro. The above parameters were determined in one group of monkeys at 210 days and in another group at 130 days after initiation of antiserum treatment. The testis of both groups of monkeys showed a marked reduction in the rate of [3H]thymidine incorporation into testicular DNA as well as in hyaluronidase activity compared to the corresponding control animals. Further, on withdrawal of antiserum treatment in one set of monkeys, a clear recovery was observed in these parameters, thus demonstrating that the earlier observed effects were specifically due to lack of FSH. The results clearly indicate that chronic lack of FSH affects testicular function in the adult monkey and it is suggested that FSH could have a positive role in spermatogenesis in the adult sub-human primate.

Item Type:Article
Source:Copyright of this article belongs to European Academy of Andrology.
Keywords:FSH and Testicular Function; Sub-human Primate; [3H]thy-midine Incorporation into Testicular DNA; Hyaluronidase Activity in Testis; Antiserum to FSH
ID Code:21640
Deposited On:22 Nov 2010 11:08
Last Modified:08 Jun 2011 11:11

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