A need for FSH in maintaining fertility of adult male subhuman primates

Moudgal, N. R. (1981) A need for FSH in maintaining fertility of adult male subhuman primates Systems Biology in Reproductive Medicine, 7 (2). pp. 117-125. ISSN 1939-6368

Full text not available from this repository.

Official URL: http://informahealthcare.com/doi/abs/10.3109/01485...


Adult fertile male bonnet monkeys (Macaca radiata) were continuously deprived of endogenous follicle stimulating hormone (FSH) support for 240 days by injecting them with 1 ml of characterized monkey antiserum to oFSH every 48 hr; control monkeys received during the same period normal monkey serum instead. Testicular function was assessed at periodic intervals by (a) carrying out differential counting of sperm in the ejaculate obtained and (b) determining the hyaluronidase activity as well as in vitro 3H thymidine incorporation into DNA of testicular tissue removed at biopsy. Both the quality (viability and motility) of the sperms voided and the total sperm counts showed marked decreases as a function of time of immunization, the first significant reduction being noted by 100 days. FSH deprivation affected both the biochemical parameters used to test testicular functionality they being reduced at ~200 days by 50%-60%. The fertility of these monkeys was evaluated at periodic times after 90 days of treatment by means of mating studies. FSH deprivation had rendered the monkeys incapable of impregnating any of the females used. Testosterone and luteinizing hormone (LH) levels remained unchanged following FSH antiserum injection. With cessation of antiserum treatment testicular function and fertility were completely restored to normalcy, indicating that the observed effect was specifically due to FSH deprivation. This study thus provides conclusive evidence for the involvement of FSH in maintenance of testicular function and fertility in the adult male primate.

Item Type:Article
Source:Copyright of this article belongs to Informa Healthcare.
Keywords:FSH; LH; Male Fertility; Male Contraception; Monkey
ID Code:21574
Deposited On:22 Nov 2010 06:45
Last Modified:08 Jun 2011 08:58

Repository Staff Only: item control page