Molecular mechanism of insulin resistance

Bhattacharya, Samir ; Dey, Debleena ; Roy, Sib Sankar (2007) Molecular mechanism of insulin resistance Journal of Biosciences, 32 (2). pp. 405-413. ISSN 0250-5991

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Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby causing insulin resistance and type 2 diabetes. However, the underlying mechanism involved is still unclear. In searching for the cause of the mechanism, it has been found that palmitate inhibits insulin receptor (IR) gene expression, leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKCε causes this reduction in insulin receptor gene expression. One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies. We provide an overview of this important area, emphasizing the current status.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Fatty Acid; Insulin Receptor; Insulin Resistance; Insulin Signalling; Novel PKC; Type 2 Diabetes
ID Code:21538
Deposited On:22 Nov 2010 06:49
Last Modified:17 May 2016 05:44

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