Estimates of the loss of main-chain conformational entropy of different residues on protein folding

Pal, Debnath ; Chakrabarti, Pinak (1999) Estimates of the loss of main-chain conformational entropy of different residues on protein folding Proteins: Structure, Function, and Bioinformatics, 36 (3). pp. 332-339. ISSN 0887-3585

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Official URL: http://www3.interscience.wiley.com/journal/6600093...

Related URL: http://dx.doi.org/10.1002/(SICI)1097-0134(19990815)36:3

Abstract

The average contribution of conformational entropy for individual amino acid residues towards the free energy of protein folding is not well understood. We have developed empirical scales for the loss of the main-chain (torsion angles, φ and ψ) conformational entropy by taking its side-chain into account. The analysis shows that the main-chain component of the total conformational entropy loss for a residue is significant and reflects intrinsic characteristics associated with individual residues. The values have direct correlation with the hydrophobicity values and this has important bearing on the folding process.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Conformation; Conformational Entropy; Hydrophobicity; Protein Folding; Protein Engineering
ID Code:21455
Deposited On:22 Nov 2010 11:21
Last Modified:17 May 2016 05:40

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