Genetic studies of human apolipoproteins. XI. The effect of the apolipoprotein C-II polymorphism on lipoprotein levels in Nigerian blacks

Sepehrnia, B. ; Kamboh, M. I. ; Adams-Campbell, L. L. ; Bunker, C. H. ; Nwankwo, M. ; Majumder, P. P. ; Ferrell, R. E. (1989) Genetic studies of human apolipoproteins. XI. The effect of the apolipoprotein C-II polymorphism on lipoprotein levels in Nigerian blacks Journal of Lipid Research, 30 . pp. 1349-1355. ISSN 0022-2275

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Official URL: http://www.jlr.org/content/30/9/1349.short

Abstract

The human apolipoprotein C-II locus exhibits genetically determined structural polymorphism in United States and African blacks. In the present study, we have investigated the effect of the apoC-II polymorphism on quantitative serum levels of total cholesterol, total high density lipoprotein (HDL) cholesterol, cholesterol in high density lipoprotein subfractions, low density lipoprotein (LDL) cholesterol, and triglycerides (TG) in a sample of 368 unrelated Nigerian blacks. The frequencies of the APOC-II1 and APOC-II2 alleles in the samples were 0.947 and 0.053, respectively. In males, the effect of the APOC-II2 allele was to lower the total serum cholesterol and LDL-cholesterol levels by 13.28 mg/dl and 10.55 mg/dl, respectively, relative to the common allele, APOC-II1. In females, the effect was to lower total plasma cholesterol by 4.49 mg/dl and LDL-cholesterol by 3.21 mg/dl. The effect of apoC-II on quantitative lipoprotein levels is shown to be independent of variation at the linked apoE locus, but the products of the two loci interact in determining overall quantitative phenotypes.

Item Type:Article
Source:Copyright of this article belongs to American Society for Biochemistry and Molecular Biology.
ID Code:21358
Deposited On:20 Nov 2010 13:03
Last Modified:17 May 2016 05:34

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