Ethnic differences in distributions of GSTM1 and GSTT1 homozygous "null" genotypes in India

Roy, Bidyut ; Majumder, Partha P. ; Dey, Badal ; Chakraborty, Madan ; Banerjee, Sanat ; Roy, Monami ; Mukherjee, Namita ; Sil, Samir K. (2001) Ethnic differences in distributions of GSTM1 and GSTT1 homozygous "null" genotypes in India Human Biology, 73 (3). pp. 443-450. ISSN 0018-7143

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Related URL: http://dx.doi.org/10.1353/hub.2001.0040

Abstract

We estimated the frequencies of GSTM1 and GSTT1 "null" homozygotes in 10 different ethnic populations of India by a genotyping method based on polymerase chain reaction. These populations, inhabiting diverse geographical locations and occupying various positions in the sociocultural hierarchy, were represented by a sample of 299 unrelated individuals. Frequencies of GSTM1 and GSTT1 "null" homozygotes varied from 20% to 79% and 3% to 39%, respectively, across the study populations. Maximum frequencies of GSTM1 and GSTT1 "null" homozygotes (79% and 39%, respectively) have been observed in the same population (Jamatia). Frequencies of homozygous "null" genotypes at the GSTM1 and GSTT1 loci show a significant positive correlation in these populations, which is contrary to expectations. A possible implication is that the two enzymes are working in tandem, instead of working in a complementary way.

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