Asymmetric synthesis of steroidal Troger's base analogues. X-ray molecular structure of methyl 3α,12α-{6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine-2,8-bisacetoxy}-5β-cholan-24-oate

Maitra, Uday ; Bag, Braja Gopal ; Rao, Photon ; Powell, Douglas (1995) Asymmetric synthesis of steroidal Troger's base analogues. X-ray molecular structure of methyl 3α,12α-{6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine-2,8-bisacetoxy}-5β-cholan-24-oate Journal of Chemical Society, Perkin Transactions 1 (16). 2049 - 2056. ISSN 0300-922X

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Official URL: http://www.rsc.org/publishing/journals/article.asp...

Related URL: http://dx.doi.org/10.1039/P19950002049

Abstract

Cyclization of compound 5c in trifluoroacetic acid/hexamethylenetetramine produces Troger's base analogue 6c in 75% yield with 70% diastereoselectivity.

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