Facile synthesis, aggregation behavior, and cholesterol solubilization ability of avicholic acid

Mukhopadhyay, Samrat ; Maitra, Uday (2004) Facile synthesis, aggregation behavior, and cholesterol solubilization ability of avicholic acid Organic Letters, 6 (1). pp. 31-34. ISSN 1523-7060

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol036073f

Related URL: http://dx.doi.org/10.1021/ol036073f

Abstract

Avicholic acid, a major constituent of the bile of several avian species, was synthesized in eight steps from readily available chenodeoxycholic acid in 9% overall yield using Breslow's remote functionalization strategy in a key step. Micelle formation and equilibrium cholesterol solubilization properties were studied for avicholate in aqueous solution.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:21191
Deposited On:20 Nov 2010 08:56
Last Modified:26 Feb 2011 09:17

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