Design and synthesis of novel chiral dendritic species derived from bile acids

Balasubramanian, R. ; Maitra, Uday (2001) Design and synthesis of novel chiral dendritic species derived from bile acids Journal of Organic Chemistry, 66 (9). pp. 3035-3040. ISSN 0022-3263

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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo0013305

Related URL: http://dx.doi.org/10.1021/jo0013305

Abstract

Bile acids have been used for the first time as the building block for the construction of dendritic units. Orthogonally functionalized 7-deoxycholic and cholic acid derivatives were synthesized. The construction of a bile acid heptamer, a nonamer, and a decamer using the convergent strategy are described in detail. Chromatographic, spectral, and optical properties of these molecules have been investigated. Molecular modeling suggests that these molecules have globular shapes with nanometric dimensions.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:21155
Deposited On:20 Nov 2010 09:00
Last Modified:26 Feb 2011 09:27

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